Ovarian Size Matters: AMH Essay Now Available

Categories: Research Publications
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Published on: June 26, 2012

Dr. J.J. Ireland presented a highly informative summary of his research into ovarian function at last year’s AETA Joint Convention.  He and his coworkers have determined that the variation in the number of follicles and oocytes  found on the ovaries can have a profound impact on ovarian function.  Specifically they found that animals with a lower antral follicle count had a lower number of morphologically healthy follicles and oocytes.  These animals had much smaller ovaries, and a decreased response to superovulation with decreased numbers of transferable embryos recovered.  They also found that a single measurement of Anti-Mullerian Hormone (AMH) is a reliable method to determine the relative antral follicle count and thus the quantity of follicles and oocytes in the ovaries.

Minitube of America, a long time sponsor of the AETA conventions, has recently announced that it is now offering  AMH assay as a service (http://support.minitube.com/PDFS/AMH_testing.pdf )  .  Important details concerning sample submission and fees are available from Minitube (800-646-4882).

This is a new and valuable tool to manage superovulations.  There will be more information presented at the 2012 Joint Convention.  Please bring your own data to contribute to the discussion.

 

Sidebar:  What is Anti-Mullerian Hormone?

AMH is a glycoprotein hormone and it is a member of the transforming growth factor-beta group.  This hormone inhibits the development of the Mullerian (paramesonephric) ducts in the male embryo.  In adult females the hormone is expressed by the granulosa cells.  It is thought to control the formation of primary follicles and thus the initiation of folliculogenesis.

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